Warner Bros. has released a new trailer for “Beetlejuice Beetlejuice,” the follow-up to the 1988 comedy-horror classic. Michael Keaton returns as the foul-mouthed, shape-shifting ghoul joined by new cast members Jenna Ortega, Willem Dafoe, Monica Bellucci and Justin Theroux. Also reprising their roles from the original film are Winona Ryder and Catherine O’Hara.

“Beetlejuice Beetlejuice” sees the Deetz clan move back into their Winter River home after a sudden death in the family. When Lydia’s (Ryder) rebellious teen daughter Astrid (Ortega) discovers a portal to the afterlife hidden in the basement, the name of the mischievous spirit Beetlejuice is inevitably repeated three times, inviting him to wreak havoc in the Deetz family home once again.

“The living, the dead… can they coexist? That’s what we’re here to find out,” Ryder’s Lydia says in the trailer.

“Beetlejuice Beetlejuice” is the latest horror title to star scream queen Ortega, who has made a name for herself as a genre staple. She previously starred in the Netflix original series “Wednesday” as the titular Addams’ family member as well as Ti West’s “X” and two installments of the rebooted “Scream” franchise. However, it was recently announced that Ortega would not return for “Scream 7” due to a scheduling conflict with “Wednesday” Season 2.

Tim Burton returns to produce and direct the “Beetlejuice” sequel from a script by “Wednesday” screenwriters Alfred Gough and Miles Millar. Executive producers include Brad Pitt, David Katzenberg, Laurence Senelick, Gough, Millar, Sara Desmond, Katterli Frauenfelder and Andrew Lary. Tommy Harper, Dede Gardner and Jeremy Kleiner serve as producers. Danny Elfman is set to compose the music for the film.

“Beetlejuice Beetlejuice” will haunt theaters starting Sept. 6. Watch the trailer below.